Researchers from the University of Navarra (Clínica Universitaria y CIMA) and the University of Leuven have studied in mice the effectiveness of stem cells from the bone marrow to treat peripheral ischemia. Research has been done with two types of cells. Mononucleated cells, in which there are stem cells, but also separate cells, have seen that in the long term they can have a negative effect, as they cause greater fibrosis, while the multipotent MAPC stem cells have given good results. The test has also been performed by separating stem cells into the type of cells needed before transplantation and the conclusion has been reached that MAPC cells are more effective when introduced interchangeably.